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Moving Beyond the Low-Fat Paradigm

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Chronic inflammation is a central amplifier of cardiometabolic and cardiovascular disease, driving endothelial dysfunction, oxidative stress, and progressive vascular injury.[1] Dietary compounds influence these pathways, including bioactive polyphenols in extra virgin olive oil (EVOO) — such as hydroxytyrosol and oleuropein — alongside monounsaturated fatty acids (MUFAs), predominantly oleic acid. EVOO exerts anti-inflammatory and antioxidant effects by modulating inflammatory signalling pathways, immune cell activity, and endothelial responses, thereby reducing vascular damage. It represents a clinically relevant dietary strategy that complements medical nutrition therapy in cardiometabolic risk management.[2][3][4] Reference(s): 1. Higashi Y. Roles of oxidative stress and inflammation in vascular endothelial dysfunction-related disease. Antioxidants. 2022 Sep 30;11(10):1958. 2. Ghazali R. Olive oil Compounds: Biological and Chemical Actions for Health-An updated review. Food Chemistry Advances. 2026 Mar 10:101273. https://www.sciencedirect.com/science/article/pii/S2772753X26000560 3. Casas R, Estruch R, Sacanella E. The protective effects of extra virgin olive oil on immune-mediated inflammatory responses. Endocrine, Metabolic & Immune Disorders—Drug Targets. 2018;18(1):23-35. https://www.researchgate.net/profile/Rosa-Casas2/publication/321135121_The_Protective_Effects_of_Extra_Virgin_Olive_Oil_on_Immune-mediated_Inflammatory_Responses.pdf 4. Milena E, Maurizio M. Exploring the cardiovascular benefits of extra Virgin Olive oil: insights into mechanisms and therapeutic potential. Biomolecules. 2025 Feb 14;15(2):284. https://www.mdpi.com/2218-273X/15/2/284

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Test Patient Awareness Video

Test Patient Awareness Video